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KMID : 1143220190620040249
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Obstetrics & Gynecology Science
2019 Volume.62 No. 4 p.249 ~ p.257
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Pituitary magnetic resonance imaging abnormalities in young female patients with hypogonadotropic hypogonadism
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Kang Ji-Yeon
Kim Sang-Heum
Kim Houn-Young
Ki Hyo-Jin
Lee Mee-Hwa
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Abstract
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Objective: To elucidate the association between clinical and laboratory characteristics and pituitary magnetic resonance imaging (MRI) abnormalities in young female patients with hypogonadotropic hypogonadism (HH).
Methods: We retrospectively investigated a series of 74 female patients (age range, 14?42 years) with normoprolactinemic HH who underwent pituitary MRI. Pubertal milestones and hormonal features of patients with small pituitary glands (PGs) and space-occupying lesions were compared with those of patients with normal PGs.
Results: The overall frequency of abnormal PGs was 35.1%, with space-occupying lesions observed in 8 patients (10.8%), and small PG observed in 18 patients (24.3%). The mean serum gonadotropin level was not different between patients with and without pituitary MRI abnormalities (P>0.05). Space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. The frequency of space-occupying lesions was higher in patients with interrupted puberty (25.0%) than in patients who did not go through puberty (4.8%) or had a normal puberty (9.8%), but were not statistically significant (P>0.05). Small PG was associated with low gonadotropin levels and type of amenorrhea (P<0.05).
Conclusion: Clinically significant space-occupying lesions were not associated with low gonadotropin levels, type of amenorrhea, or presence of secondary sex characteristics. However, the frequency of space-occupying lesions was higher in patients with interrupted puberty than in patients who did not go through puberty or who with normal puberty.
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KEYWORD
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Hypogonadotropic hypogonadism, Amenorrhea, Delayed puberty, Magnetic resonance imaging
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